Abstract
Human gastric cancer tissue specimens were obtained from 26 operated patients, gastric fundic mucosas not infiltrated by cancer cells from 27 patients, and gastric fundic mucosas from 25 non cancer patients (gastric ulcer, duodenal ulcer, gastric polyposis, and valix in cardia).
The lipid was extracted from each specimen by the method of Folch et al. The phospholipid and simple lipid were fractionated quantitatively on the silicic acid columns. The contituent fatty acid from the separated total lipid, phospholipid, and simple lipid were identified and estimated by gas chromatography.
The distribution of simple lipid in the cancer tissue increased more than that of simple lipid in the non cancer-bearing gastric mucosa, and that of simple lipid in the cancer-bearing mucosa increased conspicuously. The phospholipid in the cancer tissue was not different from those of phospholipid in the others.
It was indicated that the stearic acid content increased in the total lipid of the cancer tissue and the oleic acid decreased, but it was not markedly indicated in the phospholipid and the simple lipid. The apportment of fatty acids in the total lipid was influenced by the ratio of phospholipid and simple lipid.
