On the Serum Iodic Acid Reducing Power in Hepatic Injury, especially its Relationship with the Pattern of Serum Protein

Abstract

The author attempted to investigate the relationship between the serum iodic acid reducingpower and the pattern of serum protein in the dogs with hepatic injury and in the patientswith liver diseases respectively. The dogs used in the experiment were devided into twogroups; the one was the moderate and the other was advanced liver injury by intramuscularinjection of carbontetrachloride. The results obtained were as follows:
1) The serum iodic acid reducing power were 0.174±0.026 in normal dogs and 0.167±0.036 in healthy persons.
2) In the dogs with moderate liver injury the serum iodic acid reducing power droppedon the first day, rised up to the maximum on the third day, dropped again on the fifth day andthen went gradually up to the value before the administration of carbontetrachloride. On theother hand, in the dogs with advanced liver injury the serum iodic acid reducing power risedup to maximum on the second day and then fell gradually, but remained in high value evenon the fourteenth day. The changes of the serum iodic acid reducing power in the dogs withhepatic injury were associated with the histrogical findings of the liver, however the authorshould like to consider that the initial drop of the serum iodic acid reducing power in thedogs with moderate liver injury was due to the disharmony of the liver function.3) The serum iodic acid reducing power in the patients with liver diseases showed a highor low value with the drop of A/G ratio as compared with that of healthy persons. When A/Gratio showed a low value, the serum iodic acid reducing power was found to be abnormalalthough other important tests of liver function revealed abnormal findings, and when A/Gratio was within normal limits, the serum iodic acid reducing power was within normal limitsalthough the results of other function tests were abnormal.
From the results above mentioned, the variation of serum iodic acid reducing power inhepatic injury was considered to reflect the changes of the pattern of serum protein and alsoto be based on the disharmony of the liver function.