1979 Volume 76 Issue 8 Pages 1660-1666
Changes in various organelle's enzymes of rat intestinal mucosa reared with alcohol diet containing ethanol 36% of total calories for 4 weeks were observed, as follows :
1) Chronic ethanol administration caused inhibition of Na+-K+-ATPase and alkaline phosphatase activities.
2) Activity of succinate cytochrome C reductase in mitochondrial fraction increased significantly while that of rotenone insensitive NADH-cytochrome C reductase changed little.
3) Lysosomal enzymes such as beta-glucuronidase, acid phosphatase were not changed in activity by chronic ethanol treatment.
4) In microsomal fraction, gamma-glutamyl transpeptidase activity was found to be markedly increased, but no change in activity of glucose-6-phosphatase.
5) On the other hand, activity of glucose-6-phosphate dehydrogenase in supernatant fraction reduced.
These findings indicate that ethanol has toxic effects on small intestinal mucosa as well as on liver.
Nippon Shokakibyo Gakkai Zasshi
Nippon Shokakibyo Gakkai Zasshi Kou
