BILE ACID METABOLISM IN PATIENTS WITH RESECTION OR BYPASS OF TERMINAL ILEUM AND PROXIMA COLON

Abstract

Thin-layer and gas-liquid chromatographic analysis of bile acid were carried out in gallbladder bile obtained from nineteen patients with resection or bypass of the terminal ileum and proximal colon.
These patients had increased ratio of glycine- to taurine-conjugated bile acid. Free bile acid was detected in 79.0% of the patients. Deoxycholic acid was absent in 9 and decreased in 2 cases out of 12 examined. The percentage of chenodeoxycholic acid was increased.
Fat malabsorption was found in 66.7% of the cases received fecal 131I-triolein excretion test. Changes of bile acid composition and intestinal flora and rapid intestinal transit time seemed to cause fat malabsorption.