Abstract
Effects of phenylbutazone on biosynthesis of gastric glycoproteins were studied. UDPgalactosyl transferase activity in phenylbutazone damaged fundic gland area was not changed when compared with control. The pyloric gland area of the phenylbutazone treated group showed lower UDP-galactosyl transferase activity than the control group. When Proglumide, antiulcerous agent, was administrated to rats with gastric mucosa injured by phenylbutazone, UDP-galactosyl transferase activities in fundic and pyloric gland areas were increased when compared with the group treated only with phenylbutazone. From resalts described above it was indicated that Proglumide had antiulcerous effects by activating biosynthesis of gastric mucosal glycoprotein.
