STUDY OF LOCAL HEPATIC BLOOD FLOW OF THE RAT BY HYDROGEN CLEARANCE METHOD

Abstract

Change of local hepatic blood flow of the rat liver under various conditions was measured by hydrogen clearance method.
The results were summarized as follows.
1) There was no difference in local hepatic blood flow in different portions of hepatic lobes.
2) In hypotensive rats, those blood pressure was decreased to 65% of the normal following phlebotomy, local hepatic blood flow was decreased to 70% of the normal at the region adjacent to porta hepatis and to 63% at to peripheral region of the same hepatic lobe.
3) After ligation of hepatic artery, 22% decrease of local hepatic blood flow was observed.
4) Twenty one percent decrease of local hepatic blood flow was noted following the postural change from the supine to the upright position. When the position was returned to the supine, local hepatic blood flow was again increased to 18% of that in the upright position.
5) Local hepatic blood flow was increased to 21% following intraportal venous injection of glucagon and insulin.
6) Hepatic regeneration rate in the hepatectomized rat was accelerated following intraperitoneal injection of glucagon and insulin, but the degree of hepatic regeneration was not correlated to local hepatic blood flow.
7) Local hepatic blood flow was increased to 22% by the injection of CCL₄. The flow was increased to 53% by the administration of CC1₄ with p-Hydroxyphenyl salicylamide and the liver injury was milde.