BILE ACID AND BILIARY LIPID METABOLISM ESTIMATED IN PANCREOZYMIN-SECRETIN TEST

Abstract

In order to evaluate the bile acid and biliary lipid metabolism, bile acid, cholesterol and phospholipid were assessed in duodenal aspirates obtained at the pancreozymin-secretin test (PS test) in 114 patients. There was no significant correlation between bile acid metabolism and exocrine pancreatic function, because any of total bile acid output, maximal bile acid concentration or G/T ratio of P1 fraction did not show clear correlation with 3 factors of P-S test. However, lithogenic index calculated by the equation of Thomas significantly increased with age and reached a peak at the age of 50-59 years old, and there was a significant positive correlation between lithogenic index versus obesity (% of ideal body weight) (p<0.05). Bile acid output was significantly lower in the patients with gallstone and in those with cholecystopathy (both, p<0.01) and G/T ratio was significantly higher in the patients with gallstone (p<0.05) than in the normal subjects, while these showed no significant change in any patients with liver cirrhosis, diabetes mellitus, diarrhea or chronic pancreatitis. Any significant change in lithogenic index was not noted in all disease groups.