QUANTITATIVE ANALYSIS OF TISSUE ENZYMES THAT DIAGNOSES MALIGNANT TENDENCY OF COLON POLYP

Abstract

The purpose of the present investigation is to describe the application of the quantitative analysis of lactate dehydrogenase and glutamic-oxaloacetic transaminase in the endoscopic biopsy specimen for the determination of the tendency of malignancy of the colon polyp.
Significant differences were observed when the ratio of the LDH to GOT enzyme present in the endoscopic biopsy is taken into consideration as index.
In the normal mucosa the LCH/GOT ratio was of 1.37±0.2, in the colon polyp was of 2.58±0.8, and of 3.50±1.3 in the colon cancerous tissue.
At that time a strong correlation is seen between the LDH/GOT ratio and the grade of atypia detected by the histology. The higher the grade of atypia, an increase of the LDH/GOT ratio is noticed.
Therefore, in the cases of polyp with focal cancer, the LDH/GOT ratio is seen in close proximity of the LDH/GOT ratio found in the colon cancerous tissue.
In conclusion LDH/GOT ratio in the endoscopic biospy specimen is found to be a simple and useful diagnostic method in the existence of the tendency of malignancy of the colon polyp.