THE EFFECT OF GASTRIC ULCER PRODUCED BY TOPICAL PROCEDURE ON GASTRIC SECRETION IN CONSCIOUS FISTULA DOGS, WITH SPECIAL REFERENCE TO THE ROLE OF ADRENOCEPTOR

Abstract

The effect of gastric ulcer produced by topical procedure on gastric secretion was investigated in conscious fistula dogs. Gastric ulcer was produced by submucosal injection of acetic acid or electric cauteriztion through gastric fistula. Gastric secretion was stimulated by tetragastrin i.v. infusion. The acid output and volume of gastric juice began to decrease at 10 minutes and 20 minutes respectively after the production of ulcer, and the decrease of the output continued to the end of the experiments, one hour after the procedure. They recovered partialy by propranolol and almost completely by phentolamine administration. Gastric secretion showed no significant difference among the one before and 1, 4, 7 and 14 days after ulcer production.