COMPARATIVE STUDY OF SECRETIN TEST AND PANCREOZYMIN SECRETIN TEST IN CHRONIC PANCREATITIS

Abstract

To evaluate diagnostic significance of secretin test carried out by duodenal aspiration during 60min after a bolus i.v. injection of 100CHR units secretin in chronic pancreatitis, the secretin test was studied in 28 controls and 30 patients with chronic pancreatitis and the results were compaired with those of the corresponding post-secretin 60min period of the conventional pancreozymin secretin test in 50 controls and 43 patients with chronic pancreatitis, since Boots secretin became unavailable.
The mean values, coefficients of variation and lower normal limits in the S test were similar to those of the PS test. The fluid volume, total output of amylase and bicarbonate of the S test did not correlate significanlty with body weight in controls when secretin was given independently of body weight. Therefore, parameters were unnecessary to be expressed as per kg body weight. Frequencies of abnormality in the respective parameter and final diagnosis by the S test was similar to those by the PS test in chronic pancreatitis. The S test is as useful as the conventional test for evaluation of exocrine pancreatic insufficiency in chronic pancreatitis.