CORRELATION OF QUANTITATIVE CHANGES OF GASTRIC MUCOSAL GLYCOPROTEINS IN RESTRAINT AND WATER IMMERSION STERSS IN RATS

Abstract

Quantitative changes of gastric mucosal glycoproteins were examined during the process in restraint and water immersion stress in rats. The stomaches were isolated before stress loading, 2, 4, 6 and 8 hours after stress loading, and Ulcer Index (U.I.) was calculated. U.I. showed a trend to gradually increase after stress loading, but no more increase was noted after 6hrs, or later.
The glycoprotein in mucosa of the corpus of stomach was isolated and analysed quantitatively. The result revealed that hexose level of 5.71±0.24mg/g of dry tissue weight before stress loading was significantly decreased after 2hrs, and decreased to 75% after 6hrs and 68% after 8hrs, respectively. Changes of carbohydrate composition in gastric mucosal glycoproteins were examined during stress loading. The result showed that galactose and fucose were decreased.