Inhibition of gastric acid secretion normalizes interdigestive motor activity in the stomach in dogs

Abstract

Recently, intragastroduodenal acidity has been shown to play an important role in interdigestive gastrointestinal motility. In this study, gastrointestinal motility and intragastric pH changes were monitored simultaneously indogs, to characterize 1) the relationship between intragastric pH changes and IMC, and 2) the effects of intragastric acidity on motilin-induced phase III contractions in the gastric antrum by using secretagogues and an H₂ receptor antagonist (cimetidine).
As a result, intragastric pH showed periodic changes with gastric IMC in conscious dogs. Furthermore, motilin-induced gastric phase III contractions were inhibited by gastric acidification. But inhibition of gastric acid secretion by cimetidine normalized both the motor index and migration of the contractions.
In conclusion, gastric acid secretion may influence the sensitivity to motilin of the stomach, and play an important role in the regulation of interdigestive gastric motility.