The effect of cholecystectomy on cellular proliferation of colonic mucosa in mice

Abstract

The relationship between cholecystectomy and colonic cancer has been suggested. The effect of cholecystectomy on cell proliferation of colonic mucosa in mice was studied immunohistochemically using bromodeoxyuridine (BrdU) and anti-BrdU monoclonal antibody after sham operation and cholecystectomy. In addition, the effect of carcinogen 1, 2-dimethylhydrazine (DMH), on cellular proliferation of colonic mucosa was following. The results were obtained, (1) Cellular proliferation of colonic mucosa was increased after cholecystectomy. It was suggested that cholecystectomy influenced to the cellular proliferation of colonic mucosa in the study without carcinogen.(2) In the study using DMH, cell proliferation of colonic mucosa was increased after cholecystectomy.(3) At the time for the increased effect of DMH, cholecystectomy group tended to induce earlier proliferative effect than sham operation group.