Abstract
To find the relation between the antioxidant activity and the chemical structure, several ω, ω'-bis-(3, 4-digydroxyphenyl) alkanes have been prepared(3). In this work the activity of these compounds was examined through the Acitve Oxygen Method using fresh lard as the substrate. The results of experiments were shown in Table 1, and were summarized as follows:
(1) The activities of most of the ω, ω'-bis-(3, 4-dihydroxyphenyl) alkanes tested were ap-proximately equal or superior to that of NDGA.
(2) Among these compounds α, δ-bis-(3, 4-dihydroxyphenyl) butane was most effective and an increase or decrease of the carbon chain between the two phenyl groups led the activity to lower potency.
(3) It, is noteworthy to point out that the introduction of methyl groups into the carbon chain between the two phenyl groups of ω, ω'-bis-(3, 4-dihydroxyphenyl) butane lowered its antioxidant activity.
The authors wish to express their appreciation to Professor Dr. Y. SUMIKI for his guidance and advice.
