Nonlinear Theory and Its Applications, IEICE
Online ISSN : 2185-4106
Special Section on Recent Progress in Nonlinear Dynamics in Biological Systems
Excluded volume effect enhances the homology pairing of model chromosomes
Kazunori TakamiyaKeisuke YamamotoShuhei IsamiHiraku NishimoriAkinori Awazu
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2016 Volume 7 Issue 2 Pages 66-75

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Abstract

To investigate the structural dynamics of the homology pairing of polymers, we modeled the scenario of homologous chromosome pairings during meiosis in Schizosaccharomyces pombe, one of the simplest model organisms of eukaryotes. We consider a simple model consisting of pairs of homologous polymers with the same structures that are confined in a cylindrical container, which represents the local parts of chromosomes contained in an elongated nucleus of S. pombe. Brownian dynamics simulations of this model showed that the excluded volume effects among non-homological chromosomes and the transitional dynamics of nuclear shape serve to enhance the pairing of homologous chromosomes.

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© 2016 The Institute of Electronics, Information and Communication Engineers
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