抄録
Purpose: to clarify the configuration of the esophageal mucosal lymphatics distant from cancer using D2-40 immunohistochemistry.
Methods: D2-40 immunohistochemistry for human lymphatic epithelium was performed at sites about 10 cm anal from the pathologically examined margin of upper or mid-thoracic squamous cell carcinoma (27 patients). we measured the entire length of mucosal lymphatic vessels within a ×10 objective field (1.2 mm along the muscularis mucosae).
results: the present morphometrical study demonstrated significant individual differences in the amount of mucosal lymphatic vessels, within a range of more than 10-fold (8.4 mm-0.8 mm within an objective field). However, the difference in length of the mucosal lymphatic epithelium did not correlate with either N-factor, t-factor including cancer depth or prognosis.
Conclusion: a higher density of pre-existing mucosal lymphatic vessels may not always be correlated with larger numbers of nodal metastases. Lymphatic proliferation or dilation induced by cancer seems to occur irrespective of whether pre-existing vessels are rich or sparse.
