Effects of androgens on cultured cells derived from canine anterior cruciate ligament

Hideki OHNO; Yoko KOWATARI; Masao OWAKI; Joji OHTA; Naoshi NAKAJIMA; Kazuki YOSHIOKA; Ken-ichiro MUTOH; Toshifumi OYAMADA

doi:10.2535/ofaj.89.35

Hideki OHNO, Yoko KOWATARI, Masao OWAKI, Joji OHTA, Naoshi NAKAJIMA, Kazuki YOSHIOKA, Ken-ichiro MUTOH, Toshifumi OYAMADA

著者情報

キーワード: Androgen receptor, Anterior cruciate ligament, Cell culture, Collagen, Fibroblast

ジャーナルフリー

2012 年 89 巻 2 号 p. 35-38

DOI https://doi.org/10.2535/ofaj.89.35

詳細

抄録

Anterior cruciate ligament (ACL) fibroblasts obtained from beagle dogs were cultured in basal medium containing different concentrations of 1 to 10^-3 µM 5α-dihydrotestosterone (DHT) and in basal medium itself as a control. It was demonstrated that DHT promoted cell proliferation activity, expression of androgen receptor, and collagen synthesis in ACL fibroblasts as compared with control. These results suggest that sex hormones are involved in the sex difference seen in ACL rupture of dogs.

責任著者(Corresponding author)

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