Supplementary Studies of the Saponin-Induced Colonization of the Bone Marrow Elements in Rabbits
1. A Quantitative Study of the Colonization Pattern by Use of Radioactive Tracer
1959 年 34 巻 2 号 p. 85-94
詳細
1959 年 34 巻 2 号 p. 85-94
1. A large dose (6 mg) of saponin (E. Merk) was administered in a single, intravenous injection into adult albino rabbits, which had been intravenously injected with 200pc of inorganic P in a single dose 24 hours previously.
2. In less than 72 hours after saponin injection, there occurred a striking increase in the amount of radioactivity in the spleen and to a lesser extent also in the liver, whereas the amount of radioactivity in the bone marrow was invariably reduced to a large extent, as compared with the values for the control group without saponin injection.
3. T h e histological examination of various organs revealed a striking accumulation of immature blood cells in the spleen and liver, with a simultaneous depletion of these cells in the bone marrow.
4. The above-mentioned pattern of accumulation of im m ature blood cells in foreign organs after saponin injection was the same as that observed for the transfused marrow cells.
5. The results of radioactivity measure m ents in the spleen, liver and bone marrow was correlated with the histological findings of these organs.
