Abstract
A woman, w ho had been developementallyd elayed since her birth, further deteriorateda fter she got an episode of high fever of unknown origin at 2 years of age. At the age of 52 years, she died of liver cancer after a long-standing HB virus carrier state. Neuropathologicael xaminationr evealedb rain atrophy, narrowed white matter, myelin pallor, fibrillary gliosis and status marmoratus of the thalamus. These findings suggested the primary cause of the brain pathology in this case to be a developmental destructive process which shouldh ave taken place in the early stage of brain development.I n addition, n eurofibrillaryt angles (NFT) were noticed in the hippocampus, l ocus ceruleus and nucleusb asalis of Meynert, b ut no senile plaques were found anywhere. These NFT changes seemed to be closely resembling to those of the Fukuyama type congenital muscular dystrophy. But the reason why NFT occur in this case is still obscure and probably different from that in the Down syndromeo r in physiologicals enility
