Abstract
We studied 70 patients who took zonisamide (ZNS) in August 1994, to clarify the relation between ZNS and oligohidrosis. Twelve of the 70 patients were revealed to have oligohidrosis by the interview with patients' mothers. Six of these 12 patients were evaluated by heat loading test, which showed a decreased sweat response in all patients. Five of the 12 oligohidrotic patients were evaluated by acetylcholine (Ach) loading test and all of them showed a decreased sweat response. On two patients poor sweat responses to heat loading and Ach loading recovered after discontinuation of ZNS. These results suggest that ZNS causes dysfunction of sweat glands.
