Abstract
76 cases with neurological complications following Japanese B. encephalitis vaccination were examined. Age of onset of the neurological manifestations varied from 9 months to 61 years, 31 of 76 cases were under 5 years. 44 cases were male and 32 were female.
Among 76 cases with neurological complications, 66 had signs and symtoms of lesions of the central nervous system and 10 had clinical features of lesions of the peripheral nervous system. 66 cases with lesions of the central nervous system were classified into three groups; 13 cases with transitory convulsion, 38 cases with encephalopathy or meningoencephalomyelitis and 15 cases with occurrence or exacervation of preexisting illness.
Among 38 cases with clinical features of encephalopathy or meningoencephalomyelitis, 14 cases hadonset of the symptoms within 2 days after inoculation and 24 cases had onset from 3 to 19 days after inoculation. Neurological symptoms occurred with first inoculation in 10 cases and with second or subsequent inoculation in 13 cases. 13 cases recovered completely, 19 were left with sequelae and 6 died.
13 cases with transitory convulsion had no history of epilepsy or febrile convulsion. Time interval from inoculation to the onset of convulsion was within 2 days in 8 cases.
13 cases with transitory convulsion had no history of epilepsy or febrile convulsion. Time interval from inoculation to the onset of convulsion was within 2 days in 8 cases.
10 cases with clinical features of lesions of the peripheral nervous system had all polyneuritis. In 5 cases whose injection order was given, all had neurological symptoms with second or subsequent injection.
