NO TO HATTATSU
Online ISSN : 1884-7668
Print ISSN : 0029-0831
ISSN-L : 0029-0831
A Case of Fetal Valproate Syndrome with Intractable Wheezing Due to Submucosal Tumor below the Vocal Cord
Masao AdachiYoshiko AiEisaku Maeda
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1999 Volume 31 Issue 6 Pages 553-557

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Abstract
A full-term baby was born to an epileptic mother treated with two anti-epileptic drugs, sodium valproate and phenobarbital, throughout the pregnancy. She was given no information about the risk of teratogenesis of these drugs. At birth the patient was hypotonic and had clinical features specific for the fetal valproate syndrome. After a viral infection at three months of age, he had intractable and persistent wheezing. Suspecting the presenceo f congenital respiratory tract abnormality, w e performedt racheobronchoscopyw, hich revealed a relatively big submucosal tumor on the left trachial wall below the vocal cord. Dyspnea and wheezing were remarkably improved by tracheolaryngotomy, but he died suddenly and unexplainedly at seven months of age.
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© Japanese Society of Child Neurology
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