Abstract
The patient was a 8-year-1-month old girl. Her parents are cousins. She had had measles at 6months of age and was healthy until age 7 years and 9 months, when psychotic disorders, i. e.disturbance of memory and lethargy began to appear.
At age 8 years slurred speech began myoclonus of neck muscles and gait disturbance appearedand developed gradually.
With chief complaints of myoclonic jerk, regressive speech, and disturbance of consciousness, shewas admitted on January 26 th, 1970. At age 8 years and 2 months, spasmo-rigidity of entire musclesdeveloped to opisthotonus, responses to painful stimuli gradually diminished and finally coma occured.
In the EEG, periodic bursts of high voltage slow with sharp waves were demonstrated, the intervalsof the periodic events ranged from 5 to 6 seconds. Measles titers in serum (NT 1024→4096, HI 16→256, CF 32→128) and CSF (NT 64→612, HI 2→64, CF 8→46) had been elevated from 4 to 7 monthsafter the onset of the disease. Whereas HI and CF titers were slightly elevated, NT titers wereremarkably elevated.
Electrophoresis of concentrated spinal fluid samples revealed high levels of r-globul in (39.5%).
