Abstract
The patient was a 6 year and 7 month old boy, who had suffered from measles at the age of 8months, but his mental and motor development had been normal until the onset of the disease.
When he was 6 years and 4 months, the following symptoms appeared and progressively aggravated;lack of skill, mental deterioration, myoclonic seizures and extrapyramidal signs such as involuntarymovements and muscle rigidity.
Characteristic diffuse, high voltage slow wave bursts appeared periodically throughout the long-run EEG; the serological study showed high titers of measles virus antibody in serum and CSF.
Based on clinical and laboratory grounds as mentioned above, diagnosis of subacute sclerosingpanencephalitis was made.
Oral administration of Amantadine-hydrochloride 7.5mg/kg/daily, one of the antiviral agents, seemedto be effective in alleviating neurological signs and symptoms in this case.
