Abstract
High single-dose alternate-day prednisolone therapy was tried on 16 myasthenic children resistant to anticholinergic drugs. The effect was remarkable in five cases, good in three, slight in two, and none in six. No serious side effects were seen. The result was more pronounced as the prednisolone therapy was started earlier from the onset of the disease. The initial worsening was suggested to be associated with hypopotassemiadue to the steroid administration. The predni-solone therapy is indicated for 1) the generalized type patients resistant to anticholinergic drugs, and 2) the ocular type patients within three years from the onset of the disease and resistant to anticholinergic drugs. However, it may be tried for at least one month on other myasthenic patients.
