This report was based on 45 cases of neurolo-gical complications associated with mumps infec-tion, which were observed at the Departments of Pediatrics of Keio University, Yokosuka Kyosai Hospital and Yokohama Municipal Hospital from January 1960 to December 1973.
These results were as follows.
1) The seasonal incidence was more frequent in the spring and summer.
2) The illness occurred most commonly be-tween the third and eighth years of ilfe.
3) The onset of neurological complications was most common between two days before and se-ven days after the appearance of salivary glan-dular enlargement.
4) Based on the clinical and laboratory findings, the complications were further diagnosed as asep-tic meningitis (33 cases, 73.3%), deafness (bilate-ral 2 cases, unilateral 1 case, 6.7%), encephalitis or encephalopathy (3 cases, 6.7%), febrile convul-sion (3 cases, 6.7%), meningsm (2 cases, 4.4%), and unilateral seizure (1 case, 2.2%).
5) All of the 33 cases with aseptic meningitis showed a good recovery, whereas the cases with deafness and those with encephalitis or encepha-lopathy had poor prognosis, the loss of hearing was always persistent in the 3 cases of deafness, although 2 cases had only a short follow-up ob-servation (3 weeks, 4 months). Two of the 3 cases with encephalitis or encephalopathy were fatal.
Deafness and encephlitis or encephalopathy associated with mumps were reviewed in the literature and the need for administration of live attenuated mumps vaccine to children was dis-cussed.
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