Abstract
The term “fluorescent lipid peroxidation products (FLOP)” refers to the fluorescent chromophoric structure of age pigments “lipofuscin” or “ceroid” that accumulate in cells as the autofluorescent lysosomal storage bodies during senescence. The chemical structure and mechanisms of formation of age pigments are not known in great detail. In attempts to elucidate the mechanisms of age pigment formation, studies have been conducted to evaluate the effects of a variety of experimental manipulations on the in vivo as well as in vitro formation of FLOP. The formation and lysosomal storage of FLOP and the lipid nutrition for human health studied in our laboratory are reviewed.
