Reconsideration of Lipotoxicity and the Metabolic Syndrome

Abstract

Metabolic syndrome is today attributed to obesity-related (induced) metabolic defects. However, the essence of metabolic syndrome is ascribed to lipotoxicity caused by ectopic accumulation of lipids that damage and destroy nonadipose organs. Here, I would like to reconsider the lipotoxicity (steatosis) and the metabolic syndrome.