Studies on Reactive Oxygen Species by Means of Biomimetic Approaches

Abstract

The author explains in detail for the sensor research detecting reactive oxygen species (ROS) in vivo and for the research of antioxidant and anticancer drug as the studies on ROS by means of biomimetic approaches. Firstly, in the sensor research, he creates the electrochemical sensor that it is possible to detect and determine the quantity of ROS such as superoxide anion radical (O₂^{– ·}) in situ. Then, he obtains the knowledge for pathology and physiological actions based on ROS in various model as ischemia-perfusion, ovulation, etc. Secondly, in the drug research, he creates the antioxidant and anticancer drug on the basis of superoxide dismutase (SOD) mimics. Then, he fabricates the nano-drug delivery system (n-DDS) having a potential to act as a carcinostatic agent.