マランゴニ現象を利用したPLGAナノ粒子調製技術と実用化

笹井 愛子; 松﨑 香織; 辻本 広行; 三羽 信比古; 山本 浩充; 川島 嘉明

doi:10.5650/oleoscience.12.339

Fabrication of PLGA nano-particles utilizing the Marangoni phenomenon

Aiko SASAI, Kaori MATSUZAKI, Hiroyuki TSUJIMOTO, Nobuhiko MIWA, Hiromitsu YAMAMOTO, Yoshiaki KAWASHIMA

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Keywords: Marangoni phenomenon, PLGA, nano-particle, DDS, polymeric spherical crystallization

JOURNAL FREE ACCESS

2012 Volume 12 Issue 8 Pages 339-345

DOI https://doi.org/10.5650/oleoscience.12.339

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Abstract

Drug-loaded PLGA (poly lactic-co-glycolic acid)-nanoparticles prepared using the emulsion solvent diffusion (ESD) method applying the “Marangoni Phenomenon” developed by Kawashima’s group. This technology could be applied further to not only pharmaceutical have the function of DDS (drug-delivery-system) but also medical devices and cosmetics. In this paper, we would like to introduce a part of our research and development results.

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