Role of Enterobacteria-mediated Bile Acid Signaling in Lipid Homeostasis

Abstract

The enterobacteria biotransform bile acids as well as vitamins and short-chain fatty acids. Enterobacteria-mediated bile acid biotransformation causes the alteration of intestinal bile acid composition resulting in the regulation of host bile acid metabolism through nuclear receptor farnesoid X receptor (FXR) and protein degradation signaling. Recently, it has been reported that enterobacteria-mediated bile acid signaling is a target for the prevention of obesity. In this article, I would like to introduce the involvement of enterobacteria-mediated bile acid signaling in lipid homeostasis.