Synthesis and Application of Perfluoroalkylated Chiral α-Amino Acids

Abstract

Fluorine-containing organic compounds have been receiving significant interest in material science and pharmaceutical chemistry. Especially, fluorinated amino acids are promising compounds to contribute to the further development of biochemistry and medicinal chemistry. However the reports on stereoselective synthesis of perfluoroalkylated α-amino acids are limited. This review summarizes the synthetic methods of perfluoroalkylated amino acids based on the naturally occurring amino acids, alanine, valine, leucine, isoleucine.