2016 Volume 16 Issue 8 Pages 381-386
It is well known chiral stationary phases (CSPs) based on polysaccharide derivatives show extremely higher chiral recognition ability for a wide range of racemic compounds. Nowadays, most of people who determine optical purity of their compounds have adopted chromatographic method using polysaccharide derivatives type columns, so called, “chiral columns”. Although chiral columns based on polysaccharide derivatives are the most powerful tool for chiral separation, there have been a few chiral compounds which cannot be separated on chiral columns yet. And it has been believed that the representatives of such difficult compounds to be separated are triglycerides. But recently interesting articles have been reported about a direct chiral separation of triglyceride compounds. Here we would like to look over the chiral separation using CSPs for HPLC and introduce the current situation about polysaccharide derivatives CSPs.
