2017 Volume 17 Issue 11 Pages 549-558
In order to further develop topical dosage preparation and transdermal drug delivery systems (TDDS) as a convenient DDS, it is necessary to fully understand the skin structure and the percutaneous absorption of drugs. Here, the author explained skin penetration pathway of drugs and kinetics aspect for the percutaneous absorption of drugs as well as skin concentration profiles, which are important especially for evaluation of topical dosage preparation. In addition, the author explained about the use of skin-penetration enhancers and physical means to increase the skin permeation of drugs, which are important in practical application. Great progress of AI (artificial intelligence) and IoT (internet of things) may derive completely new types of TDDS in the near future. That is why it is time to look back on the past for the sake of the future.
