Factors Affecting Drug Dissolution from Solid Dispersion

Abstract

Dissolution improvement of poorly water-soluble drugs using solid dispersion has been investigated from the latter part of the twentieth century for the purpose of improved oral drug absorption. However, drug dissolution improvement does not always contribute to the subsequent absorption improvement. Thus, drug dissolution behavior and the dissolved state should be taken into accounts for the formulation study. In this article, effects of pharmaceutical excipients and formulation composition on drug dissolution from solid dispersion are introduced, focusing on drug dissolution behavior from solid dispersion and the dissolved state of drug.