Fatty Acid Metabolism and Gut Microbiota in Host Homeostasis

Abstract

In the past decades, many studies are reported that gut microbiota have not only to form the community in the gut but also to have a pivotal role in the human health. Especially, the alteration of gut microbiota (dysbiosis) have risk factors for human diseases, therefore, the gut microbiota has become a focus for research at the interaction between diet (key factor) and metabolic health. To date, accumulated extensive body of scientific knowledge is exhibited to the gut microbiota as a mediator of dietary impact on the host metabolism. This review will discuss the recent studies in underlying mechanisms whereby the gut microbiota modulates the effects of diet and shapes the host metabolism either towards or away from obesity and related metabolic conditions. In addition, to discuss the recent studies in relation to gut microbial metabolite of dietary lipids and host energy regulation, and evaluate for potential as novel therapeutic targets for diet-induced obesity and related metabolic disorders.