Development and Clinical Assessment of the W/O/W Emulsion Type Drug for Transarterial Injection Chemotherapy for Hepatocellular Carcinoma and the S/O/W Nano-emulsion Drug for the Use of Intravenous Injection Therapy of Hepatic Disease

Abstract

The authors developed a new technology for preparing various multiple emulsions using the membrane emulsification techniques named the direct emulsification method and the membrane permeation method. More than 800 patients bearing hepatocellular carcinoma have been treated attaining excellent results by transarterial injection chemotherapy with the W/O/W emulsion type drug, prepared by the direct emulsification method. On the other hand, our experimental trial including in vivo and in vitro fundamental researches with the S/O/W nano-emulsion drugs aimed at intravenous injection therapy for liver disease, prepared based on the membrane permeation method, showed interesting findings concerning a reticle-endotherial system evasion and the cellular targeting. We discuss that the potential of the multiple emulsion is high for medical supplies as things mentioned above.