Damage Caused by Oxidative Stress in Living Bodies and Its Defense

Abstract

Oxidative stress derived from reactive oxygen species and/or heavy metal ions causes random damages to components in living bodies, causing aging and/or various disorders. This study was undertaken in order to elucidate the molecular mechanisms of the damages to lipids, proteins and DNA caused by oxidative stress. This paper involves, lipid peroxidation induced by oxidative stress in living bodies, aging mechanisms of cells induced by oxidative stress, and OPH (oxidized protein hydrolase) as a secondary defense system against oxidative stress.