Abstract
Liposomes represent various properties of electric charge, thermo-sensitivity, pH-sensitivity and fusion by regulation of lipid composition and size. Properties of membrane control biological behavior, drug-trapping efficiency and drug-releasing property as DDS carrier. Liposomal biodistribution depends on opsonization of plasma protein which can be controlled by membrane fluidity and PEG-coating. Drug-trapping efficiency and drug-releasing property also depend on fluidity of membrane. This character is useful for thermo-sensitive liposomes. Liposomes are also used as vector of anti-sensene DNA and plasmid DNA, because these properties of liposomal membrane can introduce genes into cells. Cationic liposomes enhance the ability of DNA-packing and attachment to cells, this property increase the transfection. Functional pH-sensitive liposomes and fusogenic liposomes can improve the transfection of pDNA. Optimal liposomes with progress of biological membrane will be developed.
