Development of Artificial Blood Material Using Cyclodextrin and its Application as a Drug for Fire Gas Poisoning

Abstract

Do you know the field of biomimetic chemistry? This is an interdisciplinary research field in chemistry that focuses on producing the functions of natural biomolecules using chemically synthesized compounds. Our group has developed artificial hemoglobin compounds using cyclodextrin derivatives for many years. Our original biomimetic model complex, hemoCD, is the only example as artificial hemoglobin compounds that function in water as well as in vivo. HemoCD can transport oxygen like hemoglobin, while hemoCD strongly binds CO and excreting CO in the urine. Therefore, hemoCD shows high potential as an emergency drug for fire-gas poisoning. In this paper, we introduce our drug development research based on biomimetic chemistry.

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