Lipid Peroxidation Induced Novel Cell Death (Ferroptosis and Lipoxytosis)

Abstract

We discovered that GPx4-deficient cell death induces an ferrous iron-independent lipid oxidation mediated novel cell death, named lipoxytosis, and have identified the novel cell death executor Lipo genes by screening genome-wide shRNA library and several lipoxytosis chemical inducers and inhibitors by chemical compound library. Thus, it is becoming clear that lipid oxidation-dependent cell death regulated by GPx4 and vitamin E involves at least two distinct pathways: an iron dependent ferroptosis and an iron-independence lipoxytosis. By distinguishing between different disease states going forward, it will become possible to select new treatment options.

graphical abstract