Abstract
The PLGA-microsphere technology was introduced to the development of drug which is targeting Mycobacterium tuberculosis via phagocytosis of alveolar macrophages. In this paper, the modification and optimization of microsphere/liposome technologies with carbohydrates utilized by the interaction of cell-cell or cell-matrix will be discussed. Carbohydrates present on cell surface, play a role in cell-cell/cell-matrix interactions and regulate cell functions. Macrophage incorporates the pathogens by specific receptors for carbohydrates. These phagocytic receptors are associated with lipid rafts/membrane microdomains and these complexes function as an interface of the cell interacting with foreign bodies. This paper deals with the microsphere/liposome technologies utilizing phagocytic receptors of macrophage and lipid rafts/membrane microdomains.
