Abstract
Spindle cell carcinoma (SPCC) is a relatively rare tumor and its histogenesis is controversial, since the spindle cell feature is often difficult to differentiate from sarcomatous lesions. We report a case of SPCC arising from the base of the tongue and its cytological and immunohistochemical findings are highlighted. Cytologically, the smear revealed two kinds of tumor cells: squamous and spindle-like cells. The spindle shaped-cells showed sarcomatous features while the atypical squamous cell nuclei were hyperchromatic with increased N/C ratio. Histopathology showed SCC and proliferation of spindle shaped cells. Histochemistry revealed a moderately dense amount of collagen fibers in the stroma. Immunohistochemically, the SCC component was positive for keratin and EMA and the spindle cell component was positive for vimentin. These results were considered to support the concept of a malignant epithelial cell undergoing metaplastic alterations. The study also suggested that a proper cytological and histological recognition of this lesion is important.
