Central odontogenic fibroma of the maxilla: a case report with immunohistochemical study

Abstract

A rare case of central odontogenic fibroma of the maxilla is presented. A 29-yearold man was admitted because of movable right lateral incisor and dull pain. Panoramic radiograph showed a well-demarcated unilocular radiolucent lesion in the right anterior region of the maxilla. The enucleated tumor was a well-defined firm mass with a solid yellowish-white appearance. Histologically, the tumor was composed of minimally cellular collagenous connective tissue with myxoid matrix. Small epithelial islands were scanty, scattered and inactive appearing in the connective tissue. Immunohistochemically, the fibroblastic cells were positive for vimentin, and the epithelial islands were positive for cytokeratin 14 (CK14) and CK19, which are markers of odontogenic epithelium. From these findings, the tumor was diagnosed as an epithelium-poor type of central odontogenic fibroma. No recurrence has been noted 14 months after surgery.