抄録
This paper's purpose is to analyze temporally and spatially differential roles of Notch-1, -2 and -3 in the neurogenesis of mouse embryos. In Northern blot hybridization, Notch-1 and -3 were expressed in the nervous tissue and increased in the level from 12 to 14 day post coitum (dpc). Notch-2 was more weakly expressed than Notch-1 and -3 on 12 and 14 dpc. In in situ hybridization, Notch-1 and -3 expressions appeared early on 6 dpc. On 12, 14, and 15 dpc, high level of Notch-1 expression was observed in the ventricular zone, and Notch-3 was diffusely expressed in the ventricular, intermediate and marginal zones of the brain, and Notch-2 expression was in the lower level. These findings suggest that Notch-1, -2 and -3 play individu-ally complementary and combinatorial roles in the neurogenesis of mouse embryos.
