抄録
Serum iron was determined by Dipyridil method. Serum Copper was measured by Gubler's Diethyl-dithiocarbamate method.
(1) A significant diurnal variation was recognized in serum iron and copper of six adult subjects. The serum iron and copper showed the highest level at noon and the lowest at midnight. Namely average serum iron content was 122γ/100ml at 12. a. m. and 84γ/100ml at 12. p. m.
Average serum copper content was 102γ/100ml at 12. a. m. and 89γ/100ml at 12. p. m.
(2) Iron and copper in the blood serum were measured in seven healthy adults before and after a thermal bath in Ikaho Hot Spring and in plain water respectively at 42°C for 10 minutes. But no significant change was proved.
(3) Serum iron and copper in 9 healthy subjects were increased by acethylcholin injection. Serum iron rose 20 minutes after the injection (149γ/100ml), and returned to the former level after 60 minutes (131γ/100ml). Serum copper reached the highest value 30 minutes after the injection (111γ/100ml), and returned to the initial level after 60 minutes (100γ/ml).
(4) Serum iron and copper in 6 healthy subjects were decreased by adrenalin injection. Serum iron fell to 95γ/ml 30 minutes after the injection, and returned to the former level after 60 minutes (05γ/100ml). Serum copper fell to the lowest level 30 minutes after the injection (80γ/100ml) and returned to the former level after 60 minutes (101γ/100ml).
(5) Chlorpromazine injection decreased the serum iron in 5 subjects after 30 minutes, but it recovered to the initial level in 60 minutes.
No significant change in serum copper was caused by chlorpromazine injection. Chlorpromazine seems to suppress the diurnal variation in serum iron and copper.
