抄録
A practical method divised by the author to collect the adrenal venous blood of the rat was described. Adrenal cholesterol and comp. B and F like substances were estimated by Sperry-Webb and Sweat's method to study the effects of baths on the adrenal cortex.
Therefore adrenal cholesterol and chemocorticoids in the adrenal venous blood of 91 rats (48 hypophysectomized, 43 normal) were estimated 4 hours after a bath, and serum cholesterol of 26 rats (13 hypophysectomized, 13 normal) were compared with adrenal cholesterol after a series of daily baths during a week. And following results were obtained.
1) Thoron bath (at 37°C for 20min. or at 42°C for 15min.) and soft water bath (at 42°C) decreased the adrenal cholesterol and increased comp. B like substance in the adrenal venous blood of the normal rats.
2) Thoron bath decreased the adrenal cholesterol of normal rats after a series of baths at 42°C during a week. No such effect was seen by the soft water baths. But serum cholesterol was increased especially by the former.
3) As regards to the hypophysectomized rats, Thoron bath (at 37°C and 42°C) decreased the adrenal cholesterol, and increased comp. B like substance in the adrenal venous blood.
4) Chlorpromazine injection did not inhibit the effects of Thoron bath on the adrenals of hypophysectomized rats.
5) A series of daily baths during a week at 42°C increased the adrenal cholesterol and decreased the serum cholesterol of hypophysectomized rats especially in the case of soft water.
The facts, that hypophysectomy and chlorpromazine could not inhibit the effects of Thoron bath, suggest that there must be a direct action of Thoron to the adrenals or some by-path which transmits stmuli of the Thoron bath to the adrenals, not via pituitary or sympathicus.
