1981 Volume 44 Issue 3-4 Pages 92-97
Influence of sulphur hot spring water upon wound healing of rat skin was studied. To provide local inflammation, croton oil was injected intradermally into a previously shaved area of rat abdominal skin. Those rats were taken bath with sulphur hot spring water at 37°C for 10min a day, every second day. The increased ratio of hexosamine to hydroxyproline was observed in skin necrotized with croton oil at 4th day, because of increases in hexosamine and decreases in hydroxyproline concentrations with inflammation. After that, hexosamine and hydroxyproline concentrations of necrotic skin returned to control, uninjured levels in 10 days. In bathing with sulphur hot spring water, changes in hexosamine and hydroxyproline concentrations of necrotic area did not alter to bathing with deionized water and to non-bathing of rats.
Although influence of bathing with sulphur hot spring water was examined on glutathione metabolism in rat liver and kidney, it was observed that reduced glutathione concentration, and GSH-reductase, GSH-peroxidase and γ-glutamyl transpeptidase activities unchanged in liver and kidney for the bathing period of 14 days.
