1993 Volume 56 Issue 2 Pages 126-128
Promethazine-HCl was used to suppress histamine production in the skin by Na2SO4·NaHCO3 bathing, confirming the previous data that the small amount of histamine released as a chemical mediator may have caused the warming effect, as observed in type I allergic reaction.
The skin histamine contents after serial bathings with Na2SO4·NaHCO3 under medication of Promethazine-HCl for 3 weeks were significantly reduced compared with that of tap water (p<0.05).
The skin histamine produced by physical stimulation of Na2SO4·NaHCO3 bathing was suppressed with H1-blocker (Promethazine), verifying that the warming effect with Na2SO4·NaHCO3 bathing was caused by histamine released as a chemical mediator, as observed in type I allergic reaction.