抄録
Use of generic drugs is recommended because of their economic advantage. However, bland and generic drugs have never been compared from the view point of their pharmacological efficacy by lymphocyte immunosuppressant-sensitivity test(LIST)with 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide(MTT)assay procedure. In this study, we evaluated the pharmacological efficacy of the bland and its generic drugs of methylprednisolone sodium succinate by LIST using peripheral blood mono nuclear cells (PBMCs) obtained from one healthy volunteer. The results showed wide difference of 90％ confidence interval between IC50 logarithmic value； however, there were no statistically significant difference in IC50 logarithmic values between these drugs. We concluded from these data that immunosuppressive pharmacological efficacy of these generic methylprednisolone sodium succinate was almost equivalent to that of the bland drug. However, further investigation is recommended to evaluate and confirm the pharmacological and economic advantage between bland and generic drugs by LIST.
